The key landmark papers for interventional bronchoscopy are presented here.
First-in-human study results for the Apreo airways scaffold
Tana A, Valipour A, Ing A, Steinfort DP, Orton CM, Klooster K, Klemm T, Williamson JP, Christie JJ, Garner JL, Koster TD. Airway scaffolds for emphysema-related hyperinflation: six-month results from the BREATHE trial. American Journal of Respiratory and Critical Care Medicine. 2025 Jul;211(7):1175-84.
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Multi-centre randomised controlled study of endobronchial coils in patients with emphysema and hyperinflation. Results demonstrated modest improvements in exercise capacity, and good improvements in quality of life and lung function. acceptable safety profile.
Randomised controlled study of vapor treatment in patients with upper lobe predominant emphysema and hyperinflation. Treatment delivered in a sequential regime. The results demonstarted significant improvements in lung function, quality of life and walk distances.
Randomised open label study of endobronchial valves in patients with emphysema, hyperinflation, intact fissures and absence of collateral ventilation confirmed with Chartis procedure. significant improvements in lung function, quality of life and walk distances were observed in treated patients. Main complications were pneumothorax and valve displacement.
This was a randomised double blind sham controlled study evaluating endobronchial valves in patients with emphysema, hyperinflation and intact fissure on their CT scans. The results demonstarted significant improvements in lung function and quality of life.
Granuloma was a randomised controlled study of endobronchial or endoscopic ultrasound (EUS or EBUS) for sampling mediastinal lymph nodes compared to TBBX in patients with Stage I or II sarcoidosis. The results demonstrated that endosonography (EUS or EBUS) is more superior and safer to conventional transbronchial lung biopsy.
The EASE study was a randomised double blind sham controlled study in patients with severe emphysema on best possible treatment. Creation of new airway passages (airway bypass led to short term improvements in quality of life, exercise capacity and lung function in the treated patients.
The AIRII study was a randomised double blind sham controlled study in asthma patients.
Bronchial thermoplasty improved quality of life, asthma symptoms and reduced exacerbations.
Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma