This pooled first-in-human analysis evaluated a novel bronchoscopic airway scaffold designed to reduce hyperinflation in emphysema by enabling trapped air to escape. The treatment was technically feasible and showed meaningful improvements in lung function, symptoms, and quality of life, with an acceptable safety profile despite some procedure-related adverse events.
Tana A, Valipour A, Ing A, Steinfort DP, Orton CM, Klooster K, Klemm T, Williamson JP, Christie JJ, Garner JL, Koster TD. Airway scaffolds for emphysema-related hyperinflation: six-month results from the BREATHE trial. American Journal of Respiratory and Critical Care Medicine. 2025 Jul;211(7):1175-84.
https://pubmed.ncbi.nlm.nih.gov/40387356
Latest comprehensive textbook on respiratory medicine for trainees through to experienced clinicians. Functions as quick reminder and refresher for exit examinations.
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Multi-centre randomised controlled study of endobronchial coils in patients with emphysema and hyperinflation. Results demonstrated modest improvements in exercise capacity, and good improvements in quality of life and lung function. acceptable safety profile.
https://jamanetwork.com/journals/jama/fullarticle/2522517
Randomised controlled study of vapor treatment in patients with upper lobe predominant emphysema and hyperinflation. Treatment delivered in a sequential regime. The results demonstarted significant improvements in lung function, quality of life and walk distances.
Randomised open label study of endobronchial valves in patients with emphysema, hyperinflation, intact fissures and absence of collateral ventilation confirmed with Chartis procedure. significant improvements in lung function, quality of life and walk distances were observed in treated patients. Main complications were pneumothorax and valve displacement.
This therapy is based on thermal ablation of damaged lung with steam vapour. This in turn leads to an inflammatory reaction and fibrosis in a portion of the lung inducing lung volume reduction. Patients will be treated with the InterVapor System in 1 to 2 segments in the upper lobes of each lung (2 to 3 segments total). Patients will also receive Optimal Medical Therapy. Recruitment to open at the Royal Brompton Hospital in the near future.
This was a randomised double blind sham controlled study evaluating endobronchial valves in patients with emphysema, hyperinflation and intact fissure on their CT scans. The results demonstarted significant improvements in lung function and quality of life.
This pivotal study is currently recruiting at the Royal Brompton Hospital (contact Dr Pallav Shah at p.shah@rbht.nhs.uk. Patients are randomised to treatment with lung volume reduction coils or control and followed over one year. The coils are made from nitinol and restoring the tension in the lung. The coils are placed minimally invasively by bronchoscopy under x-ray guidance.
Granuloma was a randomised controlled study of endobronchial or endoscopic ultrasound (EUS or EBUS) for sampling mediastinal lymph nodes compared to TBBX in patients with Stage I or II sarcoidosis. The results demonstrated that endosonography (EUS or EBUS) is more superior and safer to conventional transbronchial lung biopsy.
https://jamanetwork.com/journals/jama/fullarticle/1697962
LUNG VOLUME REDUCTION COILS (LVRC’S)
Endobronchial coils for the treatment of severe emphysema with hyperinflation (RESET): a randomised controlled trial.
The Reset study assessed the clinical benefits and safety of lung volume reduction coils (LVRCs) for the treatment of patients with severe emphysema with hyperinflation.