Status: Active, not recruiting.
The Ryme Medical Lung Denervation System is a new, experimental device that consists of a balloon catheter to freeze the overactive nerves in COPD to improve symptoms of COPD. This first in human study will include up to 40 patients in 4 sites in Europe and the UK, with a 12-month post procedure follow up for patients.
Link: https://clinicaltrials.gov/study/NCT05967091
Status: Active, not recruiting.
Emphysema is a lung disease that results from damage to the walls of the alveoli of the lungs. A blockage (obstruction) may develop, which traps air inside the lungs. The Apreo Implant is designed to open lung airways, allowing trapped air to escape, thereby reducing hyperinflation of the lungs. This multi-centre study is being carried out to assess the safety, feasibility and preliminary efficacy of the Apreo Implant for severe emphysema in up to 60 participants.
Link: https://clinicaltrials.gov/study/NCT05949645
Status: Active, not recruiting.
Bronchial Rheoplasty (investigational treatment) is designed to remove the tissue layers of the airway where the abnormal mucus cells are located. It is expected the airway tissue will heal more normally after treatment, and thereby reduce the symptoms associated with chronic bronchitis, such as cough and phlegm. The purpose of the study is to assess the safety and effectiveness of Bronchial Rheoplasty for the treatment of the symptoms of chronic bronchitis in adult COPD patients with moderate to severe chronic bronchitis. A total of 270 patients will be randomised in multiple centres including in Europe, United States and Canada. study centres and up to 10 centres outside the US (Canada and Europe) and they will be followed up for 2 years.
Link: https://clinicaltrials.gov/study/NCT04677465
Status: Active, not recruiting.
The RejuvenAir® System is a cryosurgical device that applies medical-grade liquid nitrogen to the treatment area to ablate tissue in the airways that causes cough and sputum production and allow regrowth of healthier epithelial cells to reduce the symptoms associated with chronic bronchitis. This is study designed to demonstrate the safety and effectiveness of the RejuvenAir® System for the treatment of adults with a diagnosis of chronic bronchitis and COPD comparing treatment to Sham Control Arm in a 2:1 randomised control trial. Those randomized to the Sham Control Arm will have the option to cross over to the treatment arm after the 12 month follow up visit. Patients in this study will be followed for 24 months.
Link: https://clinicaltrials.gov/study/NCT03893370
Status: Recruiting
This study involves the use of the Creo Medical MicroBlate Flex instrument, to heat and destroy lung tumour cells using microwave energy. In this study, we are investigating whether the ablation instrument can be used effectively to treat lung tumours or tumours that have spread to the lungs. If successful, using this technology may mean future patients may not need to undergo surgical removal of these types of lung tumours. Up to 18 subjects (plus replacements) are enrolled in the study. All participants will undergo the microwave ablation procedure, followed by a surgical resection of the tumour up to 21 days after ablation.
Link: https://clinicaltrials.gov/study/NCT06869122?id=nct06869122&rank=1
Status: Recruiting
This is a post-market, prospective, single-arm, multicentre, non-randomized study which enrolling up to 32 subjects in total (plus replacements). The primary purpose of this study is to evaluate the safety and feasibility of the Creo Medical MicroBlate™ Flex AB1 instrument used with the AB1 electrosurgical system in patients undergoing bronchoscopic microwave ablation of peripheral lung nodules. Subjects include patients with a suitable soft tissue lung lesion, who are not surgical candidates or decline surgery. Subjects who meet the eligibility requirements undergo a pre-procedural assessment, a bronchoscopy procedure that includes ablation treatment with MicroBlate™ Flex AB1, a post-procedural assessment and 6 follow-up visits at, 7 days (by phone call or in person), 31-45 days, 3 months, 6 months, 9 months and 12 months.
Link: https://clinicaltrials.gov/study/NCT05786625
This is a prospective, open label, multi center, single arm, first in human study to assess the safety and initial performance of EAS1 system for Irreversible Electroporation (IRE) ablation of lung cancer in subjects eligible for tumour resection. Up to 15 subjects (plus replacements) are enrolled in the study.
Subjects undergo ablation of the lung tumour via Irreversible Electroporation (IRE) method performed bronchoscopically, followed by resection of the tumour up to 19 days after the ablation.
First-in-human study results for the Apreo airways scaffold
Tana A, Valipour A, Ing A, Steinfort DP, Orton CM, Klooster K, Klemm T, Williamson JP, Christie JJ, Garner JL, Koster TD. Airway scaffolds for emphysema-related hyperinflation: six-month results from the BREATHE trial. American Journal of Respiratory and Critical Care Medicine. 2025 Jul;211(7):1175-84.
https://pubmed.ncbi.nlm.nih.gov/40387356
Latest comprehensive textbook on respiratory medicine for trainees through to experienced clinicians. Functions as quick reminder and refresher for exit examinations.
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Multi-centre randomised controlled study of endobronchial coils in patients with emphysema and hyperinflation. Results demonstrated modest improvements in exercise capacity, and good improvements in quality of life and lung function. acceptable safety profile.